|
SFRBM's 16th ANNUAL MEETING PROGRAM
Program subject to change (as of May 27, 2009)
WEDNESDAY, NOVEMBER 18, 2009
8:00 am – 3:15 pm
PRE-MEETING WORKSHOP I
Critical Methods for Redox Biology: From the Test Tube to the Clinic
Chairs: Richard Cohen, MD, Boston University and
Yvonne Janssen-Heininger, Ph.D., University of Vermont
The purpose of the workshop will be to lower the threshold for the audience to use methodologies to study redox signaling in basic biological and translational research. Speakers will present theory, advantages, and disadvantages of approaches used to study different aspects of redox biology including cellular redox receptors, oxidant generating systems, targeted antioxidants, cellular redox compartments, and alteration in protein function. Each presenter will emphasize basic theory, “how to” methodology, and cutting edge advancements.
8:00 am - 8:05 am
Welcome
Richard Cohen, MD, Boston University
8:05 am – 8:45 am
Learning from the Paradigm of NFkB
Yvonne Janssen-Heininger, Ph.D., University of Vermont
8:45 am – 9:20 am
Subcellular Localization of Oxidant Generating Enzymes
John Keaney, MD, University of Massachusetts
9:20 am – 9:55 am
Sensing Redox Changes in Intracellular Compartments
Paul Schumacker, Ph.D., Northwestern University
9:55 am – 10:30 am Break
10:30 am – 11:05 am
How to Selectively Modulate the Oxidant Tone at a Subcellular Level
J. Andres Melendez, Ph.D., Albany Medical College
11:05 am – 11:40 am
What Do I Need, and How Can I Use Mass Spectrometry in Redox Biology Research?
Christian Schöneich, Ph.D., University of Kansas
11:40 am – 12:15 pm
Genome-wide mRNA array and microRNA array studies
How to do them? What to do with the results?
Hanjoong Jo, Ph.D., Emory University
12:15 pm – 1:30 pm
Lunch
1:30 pm – 2:05 pm
Identifying Redox-Sensitive Proteins Thiols
Richard Cohen, MD, Boston University School of Medicine
2:05 pm – 2:40 pm
Redox Regulation of Nitric Oxide Signaling and Critical Methodologies
Jeannette Vasquez-Vivar, Ph.D., Medical College of Wisconsin
2:40 pm – 3:15 pm
Assessment of Nitric Oxide-Dependent Vasodilation in Humans
Joseph Vita, MD, Boston University
3:30 pm – 6:00 pm
PRE-MEETING WORKSHOP II
Grantsmanship Workshop
Edward M. Postlethwait, Ph.D., University of Alabama
5:00 pm – 5:45 pm
SFRBM Member Meeting
ANNUAL MEETING BEGINS
6:00 pm - 6:10 pm
President's Welcome
Victor Darley-Usmar, Ph.D.
University of Alabama Birmingham
6:10 pm – 6:50 pm
Discovery Award Lecture
The Nox Enzyme Family: What is Past is Prologue
J. David Lambeth, MD, PhD, Emory University
7:00 pm – 8:30 pm
Welcome Reception
THURSDAY, NOVEMBER 19, 2009
SUNRISE FREE RADICAL SCHOOL
Chairs: Balaraman Kalyanaraman, Ph.D., Medical College of Wisconsin, Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil and Aimee Landar, Ph.D.,University of Alabama at Birmingham
8:00 am – 8:30 am
What Are Free Radicals?
Garry Buettner, Ph.D., The University of Iowa
8:30 am – 9:00 am
ABCs of Reactive Nitrogen Species and their Scavengers
Ohara Augusto, Ph.D., University of São Paulo, Brazil
PLENARY SESSION
Signaling at Membrane Microdomains: All Redox is Local
Chairs: Michael Espey, Ph.D., NIH and Bulent Mutus, Ph.D., University of Windsor, Canada
Plasma membrane microdomains known as lipid rafts have emerged as an archetypical signaling scaffold. Cells utilize lipid rafts to sense and organize their responses to exogenous cues. A basic understanding of membrane lipid raft components and dynamics can translate into new drug design and better therapeutic strategies.
9:30 am – 10:00 am
Redox Signalsomes in Membrane Lipid Raft Clusters of Endothelial Cells
Pin-Lan Li, MD, Ph.D., Virginia Commonwealth University
10:00 am – 10:30 am
Circulating Cardiovascular Disease Risk Factors and Signaling in Endothelial
Cell Caveolae
Philip Shaul, MD, University of Texas Southwestern Medical Center at Dallas
10:30 am – 11:00 am
Break
11:00 am – 11:30 am
Roles of Lipid Rafts and Redox in Regulating TNF Signaling and Cell Death
Zhenggang Liu, Ph.D., National Cancer Institute, NIH
11:30 am – 12:00 pm
Cholesterol-Rich Microdomains as Mediators of Signal Transduction in Cancer
Michael Freeman, Ph.D., Children’s Hospital - Boston
12:00 pm – 2:00 pm
Lunch (attendees on own)
2:00 pm – 4:40 pm
Oral presentations from submitted abstracts
(3 concurrent sessions)
4:45 pm – 6:30 pm
Formal Poster Presentations
6:30 pm – 9:30 pm
Opening Doors Event
“Negotiating for Success”
Organized by Lynette Rogers, Ph.D., Columbus Children’s Research Institute, Asma Zaidi, Ph.D., Kansas City University of Medicine & Biosciences, Aimee Landar, Ph.D, University of Alabama at Birmingham, and Sally Nelson, Ph.D., SomaLogic, Inc., and the Women in Science Committee (WIS)
6:30 pm – 8:00 pm
FRBM Editorial Board Reception
FRIDAY, NOVEMBER 20, 2009
SUNRISE FREE RADICAL SCHOOL
Chairs: Balaraman Kalyanaraman, Ph.D., Medical College of Wisconsin, Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil and Aimee Landar, Ph.D.,University of Alabama at Birmingham
8:00 am – 8:30 am
Oxidatively Generated Damage to DNA: From Model Studies to the Cell
Jean Cadet, Ph.D., INaC, CEA/Grenoble, France
8:30 am – 9:00 am
Methods for Detecting Mitochondrial DNA Damage
Scott Ballinger, Ph.D., University of Alabama at Birmingham
PLENARY SESSION
Oxidative Damage to DNA, Repair, Clinical Relevance
Chairs: Henrik Poulsen, MD, University of Copenhagen, Denmark and Kevin Moore, MD, Ph.D., Royal Free & UCL Medical School, UK
Oxidative modification to DNA can have severe consequences for the cell and has been area of interest in the field for many years. The area has had methodological challenges, but these have recently been resolved to a high degree, and solid data with clinical relevance has emerged, as well as interesting insights into basic research. This session will focus on these aspects with a special emphasis on DNA modifications in human disease.
9:30 am – 10:00 am
Targeting of DNA Repair Proteins to the Mitochondria Effects a Phenotypic Change
Susan LeDoux, Ph.D., University of South Alabama
10:00 am – 10:30 am
Mechanisms of DNA Damage in Premature Aging: Insights from Xeroderma
Pigmentosum Type D
Priscilla Cooper, University of California-Berkeley
10:30 am – 11:00 am
Break
11:00 am – 11:30 am
Incorporation of Exogenous 8-oxodG into DNA in Cells in Culture and in Mice
Paul Henderson, UC Davis Medical Center
11:30 am – 12:00 pm
Oxidative DNA Damage in Humans, Environmental and Genetic Factors of Importance and Relation to Development of Diseases
Henrik Poulsen, MD, University of Copenhagen, Denmark
12:00 pm – 2:00 pm
Lunch (attendees on own)
2:00 pm – 4:40 pm
Oral presentations from submitted abstracts
(3 concurrent sessions)
4:45 pm – 6:30 pm
Formal Poster Presentations
SATURDAY, NOVEMBER 21, 2009
SUNRISE FREE RADICAL SCHOOL
Chairs: Balaraman Kalyanaraman, Ph.D., Medical College of Wisconsin, Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil and Aimee Landar, Ph.D.,University of Alabama at Birmingham
8:00 am – 8:30 am
Flavonoids as Dietary Antioxidants: What Are They? Do We Need Them?
Balz Frei, Ph.D., Linus Pauling Institute
8:30 am – 9:00 am
Pro-oxidants or Antioxidants
Christine Winterbourn, Ph.D., Christchurch School of Medicine, New Zealand
PLENARY SESSION
Paradoxical Roles of Oxidants and Antioxidant Enzymes in Metabolism and Diseases
Chairs: Xingen Lei, Ph.D., Cornell University and Kathy K. Griendling, Ph.D., Emory University
Recent studies, in particular with genetically-manipulated animal models, demonstrate intriguing dual roles of oxidants and antioxidant enzymes in oxidative stress associated with metabolism and chronic diseases. Four leading experts from interdisciplinary fields will provide an updated, in-depth review on the physiological outcomes, molecular mechanisms, and pathological implications of altering cellular, tissue, and body status of oxidants and antioxidant enzymes.
9:30 am – 10:00 am
Role of Nox Proteins in Vascular Disease
Kathy Griendling, Ph.D., Emory University
10:00 am – 10:30 am
Protective Role of Reactive Oxygen Species in Pancreatic Beta Cells
Paul Epstein, Ph.D., University of Louisville
10:30 am – 11:00 am
Break
11:00 am – 11:30 am
Antioxidant Enzymes and Diabetes: Foes or Friends
Xingen Lei, Ph.D., Cornell University
11:30 am – 12:00 pm
Pros and Cons of Antioxidant Nutrients in Human Cancer Prevention
Cindy Davis, Ph.D., National Cancer Institute, NIH, DHHS
12:00 pm – 2:00 pm
Lunch (attendees on own)
12:15 pm - 1:30 pm
Special Lunch Session
The Hitchhiker's Guide to Publishing a Highly Cited, High Impact Manuscript
Bruce Freeman, Ph.D., University of Pittsburgh and Anthony Newman, Elsevier
AFTERNOON PLENARY SESSIONS
Ascorbic Acid: New Discoveries for an Old Vitamin
Chairs: Balz Frei, Ph.D., Linus Pauling Institute and
Maret G. Traber, Ph.D., Linus Pauling Institute
More than 70 years after its discovery, ascorbic acid remains a fascinating molecule that galvanizes scientists and the public alike. This session will cover ascorbate’s redox chemistry that underlies a myriad of biological and physiological actions, from enzyme activities to antioxidant and pro-oxidant effects to possible roles in chronic disease prevention and cancer therapy.
2:00 pm – 2:20 pm
Vitamin C Function in the Brain: Vital Role of the Ascorbate Transporter, SVCT2
James May, MD, Vanderbilt University
2:20 pm – 2:40 pm
Vitamin C as a cancer therapeutic agent: a matter of concentration and H202 production
Mark Levine, MD, NIH
2:40 pm – 3:00 pm
Vitamin C and the Regulation of HIF-1: Impact on Cell Survival in Inflammation and Cancer
Margreet Vissers, Ph.D., Christchurch School of Medicine, New Zealand
3:00 pm – 3:30 pm
Break
Redox, Recipes and Food for Thought
Chairs: Garry Buettner, Ph.D., University of Iowa and
Barry Halliwell, DSc.., National University of Singapore, Singapore
What is the science behind the popular axiom of -- you are what you eat? There is ample evidence for harm due to nutritional deficiencies and ingestion of toxic agents. In contrast, the notion of benefit from diet has been difficult to characterize beyond the test tube. The session brings together several perspectives on the nutritional requirements for redox homeostasis.
3:30 pm – 3:50 pm
Nutritional Strategies to Defuse Weapons of Mass Inflammation
Lorne Hofseth, Ph.D., University of South Carolina
3:50 pm – 4:10 pm
Combat Rations, Redox in a Pouch: Antioxidant Systems for Both Food Functionality and Physiological Effectiveness
C. Patrick Dunne, Ph.D., U.S. Army Natick Soldier Systems Center
4:10 pm – 4:30 pm
Personalized Medicine First-Hand: Overcoming Secondary Progressive MS
Terry Wahls, MD, University of Iowa Medical Center
4:30 pm – 6:30 pm
Formal Poster Presentations
7:30 pm – 9:30 pm
Closing/Awards Banquet
SUNDAY, NOVEMBER 22, 2009
SYMPOSIUM
ROS, Redox Regulation, and Redox Imaging in Cancer
Sponsored by Seahorse Bioscience
Chairs: B. Kalyanaraman, Ph.D., Medical College of Wisconsin and
Daret St. Clair, Ph.D., University of Kentucky
Increasing evidence suggests that the redox balance between ROS/RNS generation and elimination helps maintain proper function of redox-sensitive signaling proteins in tumor cells. Whereas moderate levels of ROS/RNS (low levels of oxidative stress) are essential for cancer cell proliferation and survival, higher levels of oxidants (more severe oxidative stress) cause cancer cell death. Strategies to manipulate oxidant levels and oxidant-induced cell signaling may have significant implications in cancer therapy and will be highlighted in this symposium.
9:00 am – 9:25 am
Hyperactivation of Akt and Oxidative Apoptosis in Cancer Cells
Nissim Hay, Ph.D., University of Illinois in Chicago
9:25 am – 9:50 am
Redox Magnetic Resonance Imaging: Monitoring Tumor Redox Status and Molecular/Biochemical Profiling with MRI
Murali Krishna Cherakuri, Ph.D., NCI, NIH
9:50 am – 10:15 am
Antioxidant Enzymes as Potential Targets for Cancer Cell Killing
Peng Huang, MD, Ph.D., The University of Texas MD Anderson Cancer Center
10:15 am – 10:40 am
Regulating the Regulator: MnSOD and Cancer
Daret St. Clair, Ph.D., University of Kentucky
10:45 am
Adjourn
|
