SFRBM's 15th Annual Meeting

WEDNESDAY, NOVEMBER 19, 2008

Pre-Meeting Workshop
8:00 am – 2:45 pm
Mass Spectrometry in Free Radical Research
Organized by:  Valerie O’Donnell, Ph.D., Cardiff University, UK and Ginger Lohr Milne, Ph.D., Vanderbilt University

8:00 am – 8:15 am
Welcome
Valerie O’Donnell, Ph.D., Cardiff University

8:15 am – 9:00 am
Mass Spectrometry-Based Approaches for Free Radical Research
Ian Blair, Ph.D., University of Pennsylvania

9:00 am – 9:30 am
Measurement of Eicosanoids by Mass Spectrometry
Ginger Lohr Milne, Ph.D., Vanderbilt University

9:30 am – 10:00 am
Identification and Quantitation of Glycerophospholipids by LC/MS
Stephen Milne, Ph.D., Vanderbilt University

10:00 am – 10:30 am
Break

10:30 am – 11:00 am
Proteomics Strategies for Understanding Redox Chemistry
Jay Heinecke, MD, University of Washington

11:00 am – 11:30 am
Immuno-Spin Trapping and Mass Spectrometric Characterization of Protein Radical Adducts Induced by Oxidative Damage
Leesa Deterding, Ph.D., NIEHS

11:30 am – 12:00 pm
MS-Based Redox Proteomics Identification of Oxidatively Modified Brain Proteins in Alzheimer's Disease and Mild Cognitive Impairment: Insights into Mechanisms of Neurodegeneration in and Progression of this Dementing Disorder
Allan Butterfield, Ph.D., University of Kentucky

12:00 pm – 1:15 pm
Lunch 

1:15 pm – 1:45 pm
Mass Spectrometry as a Tool to Develop Nucleic Acid Biomarkers of Free Radical Processes in Cells and Tissues
Peter Dedon, MD, Ph.D., MIT Center for Environmental Health Services

1:45 pm – 2:15 pm
Crossing the Bridge in Polyphenols Research: The Gap Between What You Deliver and What the Cell Target Encounters
Stephen Barnes, Ph.D., University of Alabama at Birmingham

2:15 pm – 2:45 pm
From Mass Spectrometry to Clinical Practice: Applying Science in the Clinic
Kevin Moore, MD, Ph.D., Royal Free & UCL Medical School, UK

5:00 pm – 6:00 pm
SFRBM Member Meeting

6:00 pm – 7:00 pm
President’s Welcome
Lifetime Achievement & Discovery Award Lectures

Discovery Award Lecture
The Tortuous Trail to SOD
Irwin Fridovch, Ph.D., Duke University and
Joe McCord, Ph.D., University of Colorado

Lifetime Achievement Lecture
The Wanderings of a Free Radical
Barry Halliwell, D.Sc., National University of Singapore

7:00 pm – 9:00 pm 
Opening Reception

9:00 pm – 12:00 am
Hospitality

THURSDAY, NOVEMBER 20, 2008

Sunrise Free Radical School
Free Radical Biology: Back to the Basics
Chairs: Ana Denicola, Ph.D., Universidad de la República – Uruguay
Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil,
Rakesh Patel, Ph.D., University of Alabama at Birmingham
Edward Postlethwait, Ph.D., University of Alabama at Birmingham

8:00 am – 8:30 am
What are Free Radicals?
Rafael Radi, MD, Ph.D., Universidad de la República – Uruguay

8:30 am – 9:00 am
What is the Oxygen Tension in vivo
Pedro Cabrales, Ph.D., University of California, San Diego

Plenary Session
Redox-Sensitive Molecular Triggers Controlling Cellular Fate and Function
Chairs: J. Andres Melendez, Ph.D., Albany Medical College and Prabhat Goswami, Ph.D., The University of Iowa

9:30 am – 10:00 am
Mitochondria as Signaling Organelles During Stress
Navdeep Chandel, Ph.D., Northwestern University

10:00 am – 10:30 am
Nrf2 Signaling in Oxidative Stress and Cell Survival
Anil Kumar Jaiswal, Ph.D., University of Maryland

10:30 am – 11:00 am
Break

11:00 am – 11:30 am
Oxidants and Antioxidants in Control of Cell Cycle Progression
Nicholas Heintz, Ph.D., University of Vermont

11:30 am – 12:00 pm
Aging and Disease: The Role of ROS-Mediated FOXO Regulation
Boudewijn Burgering Ph.D., University Medical Center Utrecht, The Netherlands

12:00 pm – 1:30 pm
Lunch (attendees on own)

1:30 pm – 2:30 pm
Poster Presentations

2:30 pm – 4:30 pm
Oral presentations from submitted abstracts (3 concurrent sessions)

•Redox Reaction Mechanisms and Novel Products
•Superoxide, Superoxide Dismutases and Oxidative Stress
•Adaptative and Regulatory Responses

click here to view the talks and presenters in each session

4:30 pm – 6:30 pm
Formal Poster Presentations

•Generation and Action of Reactive Species
•Signal Transduction and Gene Expression
•Pulmonary Diseases
•Cancer

click here to view a list of the posters to be presented

6:30 pm – 8:00 pm
FRBM Editorial Board Reception

6:30 pm – 9:00 pm
Opening Doors Event
“Transitions: Mentoring for a New Generation”
Organized by Lynette Rogers, Ph.D., Columbus Children’s Research Institute and Daniela Salvemini, Ph.D., St. Louis University,
Women in Science Committee (WIS) 

Featured Speaker:  Mary Rose Grant, Ph.D., St. Louis University
Sponsoted by BioLife Sciences, Inc.

9:00 pm - 12:00 am
Hospitality Room

FRIDAY, NOVEMBER 21, 2008

Sunrise Free Radical School
Free Radical Biology: Back to the Basics
Chairs: Ana Denicola, Ph.D., Universidad de la República – Uruguay
Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil,
Rakesh Patel, Ph.D., University of Alabama at Birmingham
Edward Postlethwait, Ph.D., University of Alabama at Birmingham

8:00 am – 8:30 am
The ABC’s of Thiol Biochemistry
Neil Hogg, Ph.D., Medical College of Wisconsin

8:30 am – 9:00 am
Oxidative Lipid Modification
Bruce Freeman, Ph.D., University of Pittsburgh

Plenary Session
Degradation of Oxidized Proteins: A Tribute to Earl Stadtman
Chairs:  Kelvin J. A. Davies, Ph.D., D.Sc., University of Southern California and Rodney Levine, MD, Ph.D., National Institutes of Health

9:30 am – 10:00 am
The Degradation of Oxidized Proteins Protects Against Oxidative Stress
Kelvin J. A. Davies, Ph.D., D.Sc., University of Southern California

10:00 am – 10:30 am
Proteasomes and Immunoproteasomes in the Degradation of Oxidized Proteins, and in Aging
Jennifer Rivett, Ph.D., University of Bristol, UK

10:30 am – 11:00 am
Break

11:00 am – 11:30 am
Protein Maintenance Failure in Cellular Aging
Bertrand Friguet, Ph.D., Universite Pierre et Marie Curie – Paris, France

11:30 am – 12:00 pm
Oxidative Protein Folding in the Early Secretory Pathway
Roberto Sitia, MD, Universita Vita-Salute San Raffaele, Italy

12:00 pm – 1:30 pm
Lunch (attendees on own)

1:30 pm – 2:30 pm
Poster Presentations

2:30 pm – 4:30 pm
Oral presentations from submitted abstracts (3 concurrent sessions)

•Lipids in Redox Biology
•Reactive Species: Biological Formation and Actions
•Signal Transduction and Gene Expression

click here to view the talks and presenters in each session

4:30 pm – 6:30 pm
Formal Poster Presentations

•Chemistry and Reaction Mechanisms
•Oxidation of Macromolecules
•Antioxidants and Novel Therapeutics
•Aging
•Neuroscience

click here to view a list of the posters to be presented

9:00 pm – 12:00 am
Hospitality Room

SATURDAY, NOVEMBER 22, 2008

Sunrise Free Radical School
Free Radical Biology: Back to the Basics
Chairs: Ana Denicola, Ph.D., Universidad de la República – Uruguay
Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil,
Rakesh Patel, Ph.D., University of Alabama at Birmingham
Edward Postlethwait, Ph.D., University of Alabama at Birmingham

8:00 am – 8:30 am
Evaluating Superoxide/Hydrogen Peroxide Detection Methods in Biological Systems: A Chemist's View
Balaraman Kalyanaraman, Ph.D., Medical College of Wisconsin

8:30 am – 9:00 am
Case study: Lung Injury and reactive species
Carl White, MD, National Jewish Medical & Research Center

Plenary Session
Metabolic Syndrome and Redox Biology
Chairs: Shannon Bailey, Ph.D., University of Alabama and
Laura Nagy, Ph.D., Cleveland Clinic Foundation

9:30 am – 10:00 am
Adiponectin – A New Link between Inflammation, Liver Disease, and the Metabolic Syndrome
Laura Nagy, Ph.D., Cleveland Clinic Foundation

10:00 am – 10:30 am
The Role of Lipid-Derived Electrophiles in Liver Disease Associated with the Metabolic Syndrome
Dennis Petersen, Ph.D., University of Colorado at Denver

10:30 am – 11:00 am
Break

11:00 am – 11:30 am
Control of Muscle Mitochondria by Insulin: Akt2-mtNos Pathway and the Metabolic Syndrome
Juan Jose Poderoso, MD, Ph.D., University of Buenos Aires, Argentina

11:30 am – 12:00 pm
Beta Cell Death by Nitric Oxide: Is it Necrosis, Apoptosis or Both?
John Corbett, Ph.D., University of Alabama at Birmingham

12:00 pm – 1:30 pm
Lunch (attendees on own)

1:30 pm – 2:30 pm
Poster Presentations

2:30 pm – 4:30 pm
Oral presentations from submitted abstracts (3 concurrent sessions)

•Cardiovascular Redox Biology and Pathology
•Antioxidant and Novel Therapeutics
•Mitochondria and Cell Profileration

click here to view the talks and presenters in each session

4:30 pm – 6:30 pm
Formal Poster Presentations

•Nitric Oxide and its Interactions
•Proteomics and Genomics
•Nutrition & Health
•Inflammation and Immunity
•Cardiovascular Diseases
•Diabetes-Metabolic Syndrome

click here to view a list of the posters to be presented

7:30 pm – 9:30 pm
Closing/Awards Banquet

9:00 pm – 12:00 am
Hospitality Room

SUNDAY, NOVEMBER 23, 2008

Symposium
Novel Redox Signaling in Cardiovascular Pathophysiology
Chairs:  Richard Cohen, Ph.D., Boston University and
Ralf Brandes, MD, Frankfurt Medical School, Germany

9:00 am – 9:25 am
Cardiovascular Actions of Hydrogen Sulfide
David Lefer, Ph.D., Albert Einstein College of Medicine

9:25 am – 9:50 am
Pathological Role of Nox Proteins
Francis Miller, Jr., MD, The University of Iowa

9:50 am – 10:15 am
Nitrite Modulates Mitochondrial Function During Ischemia/Reperfusion
Sruti Shiva, Ph.D., National Institutes of Health

10:15 am – 10:30 am
Break

10:30 am – 10:55 am
Redox Regulation of Protein Kinase G
Philip Eaton, Ph.D., King’s College London, UK

10:55 am – 11:20 am
Cyclophilin A: A Novel Mediator of Cardiovascular Pathogenesis
Bradford Berk, MD, Ph.D., University of Rochester

11:20 am – 11:45 am
Redox Control of Central Neuro-Cardiovascular Function and Disease
Robin Davisson, Ph.D., Cornell University

11:45 am
Final Comments

11:55 am
Adjourn