SFRBM's 14th Annual Meeting
November 14 - 18, 2007
Renaissance Hotel
Washington DC USA

PRE-MEETING WORKSHOP I
8:00 am – 3:30 pm
Protein Oxidation and Modification - Mechanisms, Measurement and Biological Consequences
Organized by Michael Davies, Ph.D., The Heart Research Institute, Christian Schöneich, Ph.D., University of Kansas and Charlie Glaser, Ph.D.

8:00 am – 8:30 am
Reactions of Radicals and Other Oxidants with Proteins
Michael Davies, Ph.D., The Heart Research Institute, Australia

8:30 am – 9:00 am
Mass Spectrometry Techniques to Examine Protein Modification
Christian Schöneich, Ph.D., University of Kansas

9:00 am – 9:30 am
Proteomic Identification of Sites of Protein Carbonylation and Modification
Fred Regnier, Ph.D., Purdue University

9:30 am – 10:00 am
Analysis of Protein S-Nitrosylation
Michael Forrester, Ph.D., Duke University

10:00 am – 10:30 am
Coffee Break

10:30 am – 11:00 am
Determination of the Distribution of Protein Radicals in Cells and Tissue by Immuno-Spin Trapping
Ronald Mason, Ph.D., NIEHS/NIH

11:00 am – 11:30 am
Protein Oxidation and Regulation of Cell Function
Thomas Squier, Ph.D., Pacific Northwest National Laboratory

11:30 am – 12:00 pm
Cellular Handing of Modified Proteins
Tilman Grune, Ph.D., University of Hohenheim, Germany

12:00 pm – 1:15 pm
Lunch

1:15 pm – 1:45 pm
Protein Modification by Lipid-Derived Reactive Aldehyde Species
Koji Uchida, Ph.D., Nagoya University, Japan

1:45 pm – 2:15 pm
Illuminating the Dark Side of Light: Skin Photo-Oxidative Damage as a Drug Target
Georg Wondrak, Ph.D., University of Arizona

2:15 pm – 2:45 pm
Succination of Thiol Groups in Protein: A Biomarker of Mitochondrial Dysfunction in Diabetes
John Baynes, Ph.D., University of South Carolina

2:45 pm – 3:15 pm
Post-Translational Modification of Proteins via Peroxidase/H2O2/Thiocyanate as a Mechanism Linking Inflammation, Smoking, Uremia and Atherogenesis
Stanley Hazen, MD, Ph.D., Cleveland Clinic Foundation

3:30 pm – 4:30 pm
Poster Session
Speakers will display their research and attendees will have the opportunity for one-on-one interaction.

PRE-MEETING WORKSHOP II
2:00 pm – 5:00 pm
Media Training 101
Featured Speakers: Susan T. Borra, RD, President, International Food Information Council (IFIC) Foundation and Jeff Strei, Director, Media Relations, IFIC Foundation
Organized by B. Louise Giles, MD, University of Manitoba, Canada, Asma Zaidi, Ph.D., Kansas City University of Medicine & Biosciences and Naomi Fukagawa, MD, Ph.D., University of Vermont

PRE-MEETING WORKSHOP III
4:00 pm – 5:30 pm
Free Radicals in Biology and Medicine
Mini symposium to honor Dr. Daniel Gilbert, “A Radical Spirit”
Sponsored by the Oxygen Club of Greater Washington DC Area
Organized by Jayasree Nath, Ph.D., Walter Reed Army Institute of Research

4:00 pm – 4:10 pm
Welcome and Introduction

4:10 pm – 4:35 pm
Role of Nitric Oxide/Oxidative Balance in Chronic Neuro-Degenerative Disease
Carol Colton, Ph. D., Duke University Medical Center

4:35 pm – 5:00 pm
Imaging with Radicals
James Mitchell, Ph.D., NCI, NIH

5:00 pm – 5:25 pm
Early-Phase Ionizing Radiation Response—Use of Molecular Biomarkers for Biodosimetry Applications
William Blakely, Ph.D., Uniformed Services University of the Health Sciences

5:25 pm – 5:30 pm
Closing Remarks

ANNUAL MEETING BEGINS
6:00 pm
Welcome and Introduction
Rafael Radi, MD, Ph.D., Universidad de la República - Uruguay

6:10 pm – 7:00 pm
Lifetime Achievement & Discovery Award Lectures           

7:00 pm – 9:00 pm
Opening Reception

9:00 pm – 12:00 am
Hospitality

THURSDAY, NOVEMBER 15, 2007

SUNRISE FREE RADICAL SCHOOL
Chairs: Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil, Rakesh Patel, Ph.D., University of Alabama at Birmingham and Edward Postlethwait, Ph.D., University of Alabama at Birmingham

8:00 am – 8:30 am
What Are Free Radicals?
Garry Buettner, Ph.D., The University of Iowa

8:30 am – 9:00 am
Rates of Radical Production in Biological Tissues
Matthew Grisham, Ph.D., LSU Health Sciences Center  

9:30 am – 10:00 am
Selectivity in Biological Responses to Nitric Oxide
Michael Marletta, Ph.D., University of California, Berkeley

10:00 am – 10:30 am
Endosomal Regulation of NADPH Oxidases in Cell Signaling
John Engelhardt, Ph.D., University of Iowa

10:30 am – 11:00 am
Coffee Break

11:00 am – 11:30 am
Redox Regulation of Ras Superfamily GTPases
Sharon Campbell, Ph.D., University of North Carolina at Chapel Hill

11:30 am – 12:00 pm
Lipid Oxidation Products and Protein Damage: Analysis and Consequences
Dan Liebler, Ph.D., Vanderbilt University

12:00 pm – 12:30 pm
Annual Business Meeting 

1:30 pm – 2:30 pm
Poster Presentations

2:30 pm – 4:30 pm
Oral presentations from submitted abstracts
(3 concurrent sessions)

4:30 pm – 6:30 pm
Formal Poster Presentations 

6:30 pm – 8:00 pm
FRBM Editorial Board Reception

6:30 pm – 9:30 pm
Opening Doors Event: Linking Emotional Intelligence to Success in Scientific Careers
Sponsored by BioLink Life Sciences, Inc.
Featured Speaker: Bonalyn Mosteller, Ed.D., Senior Organizational Effectiveness Professional
Organized by by Rama Dey-Rao, Ph.D., Roswell Park Cancer Institute and Maureen Gwinn, Ph.D., NIOSH, Women in Science Committee

9:00 pm – 12:00 am
Hospitality Room

FRIDAY, NOVEMBER 16, 2007

SUNRISE FREE RADICAL SCHOOL
Chairs: Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil, Rakesh Patel, Ph.D., University of Alabama at Birmingham and Edward Postlethwait, Ph.D., University of Alabama at Birmingham

8:00 am – 8:30 am
How Does Reaction vs Diffusion Regulate ROS/RNS Biology
Jack Lancaster, Jr., Ph.D., University of Alabama at Birmingham 

8:30 am – 9:00 am
Antioxidants
Henry Forman, Ph.D., University of California, Merced

PLENARY SESSION
Free Radicals, Oxidants and Antioxidants in the Neglected Diseases: Focus on Trypanosomiasis and Leishmaniasis
Chairs: Harry Ischiropoulos, Ph.D., Stokes Research Institute and Rafael Radi, MD, Ph.D., Universidad de la República – Uruguay

9:00 am – 9:30 am
Structure and Function of the Glutathione Peroxidase-type Tryparedoxin Peroxidase: An Essential Antioxidant Enzyme of African Trypanosomes
R. Luise Krauth-Siegel, Ph.D., Heidelberg University, Germany

9:30 am – 10:00 am
Ascorbate Biosynthesis and Function in Trypanosomatids
Shane Wilkinson, Ph.D., Queen Mary, University of London, England

10:30 am – 11:00 am
Coffee Break

11:00 am – 11:30 am
Structural Studies of Trypanosomal and Mycobacterial Peroxiredoxins
Pedro Alzari, Institut Pasteur, Paris, France

11:30 am – 12:00 pm
Apoptotic Mimicry: A New Leishmanial Escape Mechanism from the Microbicidal Activity of Macrophages
Marcello Barcinski, MD, Ph.D., University of São Paulo, Brazil

1:30 pm – 2:30 pm
Poster Presentations

2:30 pm – 4:30 pm
Oral presentations from submitted abstracts
(3 concurrent sessions)

4:30 pm – 6:30 pm
Formal Poster Presentations

9:00 pm – 12:00 am
Hospitality Room

SATURDAY, NOVEMBER 17, 2007

SUNRISE FREE RADICAL SCHOOL
Chairs: Alicia Kowaltowski, Ph.D., University of São Paulo, Brazil, Rakesh Patel, Ph.D., University of Alabama at Birmingham and Edward Postlethwait, Ph.D., University of Alabama at Birmingham

8:00 am – 8:30 am
How to Measure ROS and RNS in Biology
Paolo Di Mascio, Ph.D., University of São Paulo, Brazil

8:30 am – 9:00 am
Case Study -- Impact of Free Radical Research on Disease: The Story of MPO
Stanley Hazen, MD, Ph.D., Cleveland Clinic Foundation

PLENARY SESSION
Regulation of Oxidative Stress and Inflammation: Focus on Heme Oxygenase-1 and Nitric Oxide
Chairs: Matthew Grisham, Ph.D., LSU Health Sciences Center and Jayasree Nath, Ph.D., Walter Reed Army Institute of Research

9:30 am – 10:00 am
The Many Faces of Heme Oxygenase-1
Phyllis A. Dennery, MD, University of Pennsylvania

10:00 am – 10:30 am
Mechanisms of Anti-Inflammatory Effects of Heme Oxygenase-1
Augustine M.K. Choi, MD, University of Pittsburgh

10:30 am – 11:00 am
Coffee Break

11:00 am – 11:30 am
Regulation of T-helper Cell Expansion During Inflammation: Interactive Role of Nitric Oxide and Superoxide
Roel van der Veen, Ph.D., University of Southern California

11:30 am – 12:00 pm
Regulation of L-arginine - Availability by Myeloid Cells: Effects on T-cell Function
Juan Ochoa, MD, FACS, University of Pittsburgh

1:30 pm – 2:30 pm
Poster Presentations

2:30 pm – 4:30 pm
Oral presentations from submitted abstracts
(3 concurrent sessions)

4:30 pm - 6:30 pm
Formal Poster Presentations

7:30 pm – 9:30 pm
Closing/Awards Banquet

9:00 pm – 12:00 am
Hospitality Room

SUNDAY, NOVEMBER 18, 2007

SYMPOSIA
Functional and Biological Activities of Natural and Synthetic Antioxidants
Chairs: Ines Batinic-Haberle, Ph.D., Duke Medical Center and Maret Traber, Ph.D., Linus Pauling Institute 

8:30 am – 8:55 am
Molecular Mechanisms By Which Tocopherol Transfer Protein Facilitates Hepatic Tocopherol Secretion
Danny Manor, Ph.D., Case Western Reserve University

8:55 am – 9:20 am
PXR- and EpRE-mediated Gene Expression by Dietary Antioxidants
Regina Brigelius-Flohé, Ph.D., German Institute of Human Nutrition, Germany

9:20 am – 9:45 am
A New Role for Vitamin C in Immune Cell Function and Its Impact on the Resolution of Inflammation
Margret Vissers, Ph.D., Christchurch School of Medicine, New Zealand 

9:45 am – 10:10 am
Epigallocatechin Gallate, A Green Tea Polyphenol, Ameliorates Metabolic Syndrome Abnormalities
Michael Quon, MD, Ph.D., NCCAM/NIH

10:10 am – 10:30 am
Break 

10:30 am – 10:55 am
Design and Biodistribution of Mn Porphyrin-based Therapeutics for Oxidative Stress
Ines Batinic-Haberle, Ph.D., Duke University

10:55 am – 11:20 am
Scavenging Peroxynitrite and Carbonate Radical by Metalloporphyrins In Vitro and In Vivo
Gerardo Ferrer-Sueta, Ph.D., Universidad de la República – Uruguay

11:20 am – 11:45 am
Superoxide Dismutase Mimetics and Peroxynitrite Decomposition Catalysts as Adjuncts to Opiates in Pain
Daniela Salvemini, Ph.D., St. Louis University

11:45 am – 12:10 pm
Nitrones and Age-Related Diseases
Robert Floyd, Ph.D., Oklahoma Medical Research Foundation

12:10 pm
ADJOURN