SFRBM's 12th Annual Meeting
November 16-20, 2005 • Hilton Austin • Austin, Texas USA

Wednesday, November 16, 2005

Pre-Meeting Workshop I:
Rigorous Detection and Identification of Free Radicals in Biology and Medicine
Chairs: Ron Mason, Ph.D., NIH/NIEHS and Garry Buettner, Ph.D., The University of Iowa

8:00 am - 8:25 am
Introduction to Electron Spin Resonance and Spin Trapping
Michael Gunther, Ph.D., West Virginia University

8:25 am - 8:50 am
Application Techniques of Electron Spin Resonance and Immuno-Spin Trapping
Ron Mason, Ph.D, NIEHS

8:50 am - 9:15 am
Spin Trapping of Protein Radicals
Ohara Augusto, Ph.D., University of Sao Paulo

9:15 am - 9:40 am
Immuno-Spin Trapping Detection of Protein- and DNA-Centered Radicals: In vitro and In vivo
Dario Ramirez, Ph.D., NIH/NIEHS

9:40 am - 10:05 am
Ascorbate Radical as a Real-time Marker of Oxidative Stress: Challenges and Opportunities with Transition Metals
Garry Buettner, Ph.D., The University of Iowa

10:05 am - 10:30 am
Coffee Break

10:30 am - 10:55 am
In vivo Detection of lipid-derived Free Radicals
Keizo Sato, Ph.D., Kumamoto University - Japan

10:55 am - 11:20 am
Identification of Protein Free Radicals Using Mass Spectrometry
Leesa Deterding, Ph.D., NIH

11:20 am - 11:45 am
Detection of Superoxide with DMPO and Improved Nitrones
Jeannette Vasquez Vivar, Ph.D., Medical College of Wisconsin

11:45 am - 12:10 pm
Detection of ROS with DCFH
Marta Wrona, Ph.D., Gray Laboratory Cancer Research Trust

12:10 pm - 1:25 pm
Lunch

1:25 pm - 1:50 pm
DHE and the Specific Detection of Superoxide
Balaraman Kalyanaraman, Ph.D., Medical College of Wisconsin

1:50 pm - 2:15 pm
Detection of Superoxide with Hydroxylamines
Sergey Dikalov, Ph.D., Emory University

2:15 pm - 2:40 pm
NO· Detection via EPR
Neil Hogg, Ph.D., Medical College of Wisconsin

2:40 pm - 3:05 pm
NO· Detection via Chemiluminescence and Fluorescence
Martin Feelisch, Ph.D., Boston University School of Medicine

3:05 pm - 4:30 pm
Workshop Poster Session

Pre-Meeting Workshop II
Your Winning Edge: The Art of Landing the Job You Want
Chairs: Sally Nelson, PhD, University of Colorado and Freya Schafer, Ph.D., The University of Iowa

2:45 pm - 3:00 pm
Welcome and Opening Remarks

3:00 pm - 4:00 pm
Presentation: The Art of Landing the Job You Want

4:10 pm - 5:30 pm
Discussion on specific topics such as: interviewing skills, networking, communication skills, CV/cover letters, and negotiations with invited senior scientists leading the discussion.

5:30 pm - 5:45 pm
Wrap-Up

6:00 pm - 7:00 pm
SFRBM Annual Membership Meeting

7:00 pm - 9:00 pm
Opening Reception

9:00 pm - 12:00 am
Hospitality

Thursday, November 17, 2005

Sunrise Free Radical School
Chairs: Tak Yee Aw, PhD, LSU Health Sciences Center and
Kenneth Hensley, PhD, Oklahoma Medical Research Foundation

8:00 am - 8:45 am
The Janus Face of Reactive Species in Biology
Matthew Grisham, Ph.D., LSU Health Sciences Center

8:45 am - 9:30 am
Biochemical Determinants Governing Redox Regulated Changes in Gene Expression and Chromatin Structure
Frederick Domann, Ph.D., The University of Iowa

Plenary Session - Redox Regulation of Gene Expression and Chromatin Remodeling:
Impact on Physiology and Disease
Chairs: Sonia Flores, PhD, Webb-Waring Institute and Margaret Tome, PhD, University of Arizona

10:00 am - 10:30 am
Redox Regulation of Chromatin Modeling in Response to Cigarette Smoke: Impact on Pro-inflammatory Gene Transcription
Irfan Rahman, Ph.D., University of Rochester Medical Center

10:30 am - 11:00 am
The Impact of Chronic Metabolic Oxidant Stress on CREB Function in the Vasculature
Jane Reusch, MD, University of Colorado Health Sciences Center

11:00 am - 11:30 am
Break

11:30 am - 12:00 pm
Reactive Oxygen Species in Hepatitis C Virus (HCV) Infection: Current Trends, Significance and Controversies
Jinah Choi, Ph.D., University of California - Merced

12:00 pm - 12:30 pm
Redox Regulation of the Human MnSOD 2 Gene in Normal and Tumor Cells
Daret St. Clair, Ph.D., University of Kentucky

2:00 pm - 4:40 pm
Oral presentations from submitted abstracts (3 concurrent sessions)

1. Gene Expression: ROS and RNS
2. Oxidative Environmental Challenges
3. Peroxidases, Oxidases and Thiols

4:45 pm - 6:30 pm
Formal poster presentations

1. Free Radical Chemistry (#1-17)
2. Metals, Metalloproteins and Redox Reactions (#18-29)
3. Sources of Reactive Species (#30-50)
4. Antioxidants, Nutrition and Health (#51-98)
5. Inflammation (#99-138)
6. Neuroscience (#139-163)

6:30 pm - 8:00 pm
FRBM Editorial Board Reception

9:00 pm - 12:00 am
Hospitality Room

Friday, November 18, 2005

Sunrise Free Radical School
Chairs: Tak Yee Aw, PhD, LSU Health Sciences Center and
Kenneth Hensley, PhD, Oklahoma Medical Research Foundation

8:00 am - 8:45 am
Enzymatic Oxidation of Lipids: Mechanisms and Functions
Valerie O'Donnell, Ph.D., Cardiff University

8:45 am - 9:30 am
Detection of Lipid Peroxidation Products from Free Radical and Enzymatic Processes
Jason Morrow, MD, Vanderbilt University

Plenary Session - Formation, Metabolism and Novel Signaling Pathways of Leukotrienes and Prostanoids
Chairs: Valerie O'Donnell, PhD, Cardiff University and
Jason Morrow, MD, Vanderbilt University

10:00 am - 10:30 am
The 12/15-lipoxygenase Family: Structure, Function and Biological Implication in Inflammation and Atherogenesis
Hartmut Kuhn, Ph.D., Humboldt University - Germany

10:30 am - 11:00 am
Consequences of COX-2 selectivity toward Substrates and Inhibitors
Lawrence Marnett, Ph.D., Vanderbilt University

11:00 am - 11:30 am
Break

11:30 am - 12:00 pm
Leukotriene A4: The Chemically Unstable Intermediate in Leukotrienes Biosynthesis That Won’t Go Away
Robert Murphy, Ph.D., University of Colorado

12:00 pm - 12:30 pm
Lipoxins and DHA-derived Docosanoids: Mapping Resolutions
Charles Serhan, Ph.D., Harvard University

12:40 pm - 2:00 pm
Grantsmanship Workshop for Young Investigators
Ed Postlewait, PhD, University of Alabama at Birmingham

2:00 pm - 4:40 pm
Oral presentations from submitted abstracts (3 concurrent sessions)

1. Lipid Mediators in Health and Disease
2. Oxygen: Its' Ups and Downs
3. Nitric Oxide: Biochemistry and Biology

4:45 pm - 6:30 pm
Formal poster presentations

1. Signal Transduction and Gene Expression (#164-213)
2. Nitric Oxide: Physiology & Medicine (#214-260)
3. Nitric Oxide: Chemistry & Biochemistry (#261-293)
4. Photobiology (#294-298)
5. Techniques in Free Radical Biology (#299-318)
6. Radiation (#319-325)

9:00 pm - 12:00 am
Hospitality Room

Saturday, November 19, 2005

Sunrise Free Radical School
Chairs: Tak Yee Aw, PhD, LSU Health Sciences Center and
Kenneth Hensley, PhD, Oklahoma Medical Research Foundation

8:00 am - 8:45 am
The Challenges of the Newborn
James Friel, Ph.D., University of Manitoba

8:45 am - 9:30 am
Mitochondria, Antioxidants, and Aging
Holly van Remmen, Ph.D., University of Texas - San Antonio

Plenary Session - Coping with Oxidants: A Lifetime of Challenges
Chairs: James Friel, Ph.D., University of Manitoba and
Christiaan Leeuwenburgh, Ph.D., University of Florida

10:00 am - 10:30 am
Parenteral Nutrition: A Source of ROS and Alteration of Vitamin Metabolism
Phillippe Chessex, MD, Children's and Women's Health Center of British Columbia

10:30 am - 11:00 am
Free Radicals and the Etiology of Disease in the Premature Infant
Ola Didrik Saugstad, MD, Ph.D., University of Oslo - Norway

11:00 am - 11:30 am
Break

11:30 am - 12:00 pm
Your Changing Free Radical Biology: Time Marches On
Christiaan Leeuwenburgh, Ph.D., University of Florida

12:00 pm - 12:30 pm
Polymorphisms in Antioxidant Enzymes: Cancer Risk and Outcomes
Christine Ambrosone, Ph.D., Roswell Park Cancer Institute

12:40 pm - 2:00 pm
Opening Doors: Food and Thought: Leading the Laboratory
organized by Margaret Briehl, PhD, University of Arizona (Women in Science Committee)

2:00 pm - 4:40 pm
Oral presentations from submitted abstracts (3 concurrent sessions)

1. Aging and Renewal
2. Antioxidants, Nutrition and Health
3. Oxidation and Nitration: Consequences and Function

4:45 pm - 6:30 pm
Formal poster presentations

1. Oxidation of Macromolecules - DNA, Lipid, Protein, Carbohydrate (#326-366)
2. Tissue/Cell Targets and Reactions (#367-393)
3. Cell Cycle and Apoptosis (#394-410)
4. Clinical Topics (#411-433)
5. Environmental Oxidants (#434-444)
6. Cancer (#445-477)
7. Free Radicals in Prokaryotes and Plants (#478-479)
8. Emerging Fields (#480-486)

7:30 pm - 9:30 pm
Closing/Awards Banquet

9:30 pm - 12:00 am
Hospitality Room

Sunday, November 20, 2005

Sunrise Free Radical School
Chairs: Tak Yee Aw, PhD, LSU Health Sciences Center and
Kenneth Hensley, PhD, Oklahoma Medical Research Foundation

8:00 am - 8:35 am
Nitrated Fatty Acids: Formation and Actions
Bruce Freeman, Ph.D., University of Alabama at Birmingham

8:35 am - 9:15 am
SFRBM Lifetime Achievement Award Lecture
Doxorubicin-induced Cardiotoxicity and Antitumor Action: New Mechanistic Perspectives
Balaraman Kalyanaraman, Ph.D., Medical College of Wisconsin

9:15 am - 9:55 am
SFRBM Discovery Award Lecture
Peroxiredoxin as an Antioxidant Enzyme and Active Signaling Modulator
Sue Goo Rhee, Ph.D., NIH

Plenary Session: Frontiers in Free Radical Research
Chair: Garry Buettner, Ph.D., The University of Iowa

10:00 am - 10:25 am
Fatty Acid Transduction of Nitric Oxide Signaling
Francisco Schopfer, Ph.D., University of Alabama at Birmingham

10:25 am - 10:50 am
Darth Vitamin: Has E Gone to the Dark Side?
Maret Traber, Ph.D., Oregon State University

10:50 am - 11:15 am
Killing of Mucoid Pseudomonas Aerungiosa with Nitric Oxide
Daniel Hasset, Ph.D., University of Cincinnati

11:15 am - 11:40 am
Vascular Iron Deposition and Oxidative Stress as Mediated by Palmitate
Dachun Yao, MD, Ph.D., Albert-Einstein College of Medicine

11:40 am - 12:05 pm
Mitochondrial Directed Antioxidants
Michael Murphy, Ph.D., Cambridge University - UK

ADJOURN