SFRBM's 18th ANNUAL MEETING PROGRAM
Program subject to change (as of September 30, 2011)
WEDNESDAY, NOVEMBER 16, 2011
9:00 am – 4:15 pm
PRE-MEETING WORKSHOP
Lipid Oxidation: An Overview of Methods, Products, and Functional Effects In Vivo
Chairs: Kevin Moore, MD, Ph.D., University College London, UK and Stan Hazen, MD, Ph.D., Cleveland Clinic Foundation
9:00 am – 9:25 am
Lipid Oxidation in Biology: An Overview
Garry Buettner, Ph.D., The University of Iowa
9:25 am – 9:50 am
Assessment of Lipid Peroxidation
Kevin Moore, MD, Ph.D., University College London, UK
9:50 am – 10:15 am
Measurement of F2-Isoprostanes and Isofurans
Ginger Milne, Ph.D., Vanderbilt University
10:15 am – 10:50 am
Identification of Lipid Oxidation Adducts and Functional Analysis as Receptor Ligands
Koji Uchida, Ph.D., Nagoya University
10:50 am – 11:15 am
Break
11:15 am – 11:40 am
Analysis of Phospholipid and Neutral Lipid Oxidation Products Formed in vitro and in vivo
Robert Murphy, Ph.D., University of Colorado - Denver
11:40 am – 12:15 pm
Nitrated Lipids: How to Make Them, How to Measure Them and Avoiding Artifact
Francisco Schopfer, Ph.D., University of Pittsburgh
12:15 pm – 12:40 pm
Analytical Strategies for Characterization of Bile Acid and Oxysterol Metabolomes
William Griffiths, BSc, Ph.D., CChem, MRSC, Institute of Mass Spectrometry, UK
12:40 pm – 1:45 pm
Lunch
1:45 pm – 2:10 pm
Chlorinated Lipids in Cardiovascular Disease: An Introduction to Myocardial Lipidomics
David Ford, Ph.D., St. Louis University
2:10 pm – 2:35 pm
Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation
Karsten Gronert, Ph.D., University of California, Berkeley
2:35 pm – 3:00 pm
The Lipid Whisker Model of Oxidized Cell Membranes
Stan Hazen, MD, Ph.D., Cleveland Clinic Foundation
3:00 pm – 3:25 pm
Interesting Things about PAF and PAF acetyl-hydrolase That You Never Knew
Tom McIntyre, Ph.D., Cleveland Clinic
3:25 pm – 3:50 pm
Generation and Biological Effects of y-ketoaldehydes (isoketals)
Jack Roberts, II, MD, Vanderbilt University
3:50 pm – 4:15 pm
Final Comments
ANNUAL MEETING BEGINS
5:30 pm – 5:40 pm
SFRBM President's Welcome
Harry Ischiropoulos, Ph.D., Children's Hospital of Philadelphia Research Institute
ORAL PRESENTATIONS FROM SUBMITTED ABSTRACTS
3 highest scored abstracts of 500 submitted for meeting
5:40 pm - 6:00 pm
Nitric oxide prevents diet-induced obesity by regulating adipose tissue phenotype
Brian Sansbury, University of Louisville
6:00 pm - 6:20 pm
Superoxide promotes chemoresistance via the selective inhibitory tyrosine nitration of protein phosphatase 2A-B56δ subunit and the accumulation of activated S70-phosphoBcl-2
Ivan Low, National University of Singapore
6:20 pm - 6:40 pm
Cys42Ser substitution in murine protein kinase G 1alpha eliminates oxidant sensing to cause hypertension
Oleksandra Prysyazhna, King's College London
6:40 pm – 7:00 pm
SFRBM MINI-FELLOWSHIP RESEARCH PRESENTATION
Towards understanding the role of Nrf1 in the antioxidant gene expression: the competition between Nrf1 and Nrf2
Research presentation from past recipient
Nikolai Chepelev, Ph.D., Carleton University - Canada
7:00 pm – 9:00 pm
Welcome Reception
THURSDAY, NOVEMBER 17, 2011
SUNRISE FREE RADICAL SCHOOL
Back to the Basics
Chairs: Brian Day, Ph.D., National Jewish Medical & Research Center and Sruti Shiva, Ph.D., University of Pittsburgh
8:00 am – 8:30 am
Regulation of Cell Identity by a Changing Epigenetic Landscape
Brian O’Connor, Ph.D., National Jewish Medical & Research Center
8:30 am – 9:00 am
Sirtuin 3: A Mitochondrial Watchdog Protein
David Gius, MD, Ph.D., Vanderbilt-Ingram Cancer Center
PLENARY SESSION
Redox Regulation by Epigenetics
Chairs: Ralf Brandes, MD, Goethe-University, Frankfurt, Germany and Rodney Folz, MD, Ph.D., University of Louisville
The recent progress in understanding of epigenetics has opened up a new layer of complexity in the regulation of gene expression. MicroRNAs and histone modifying enzymes as mediators of epigenetic control are subject to a complex redox-regulation affecting their expression and activity. In these sessions, the principles of epigenetic control will be outlined and the impact of redox-regulation on epigenetics, and vice versa, will be discussed with a particular focus on microRNAs, histone methylation and histone acetylation.
9:30 am – 10:00 am
Control of Antioxidant Activities by microRNAs During Red Blood Cell Development
Mitchell Weiss, MD, Ph.D., Children's Hospital of Philadelphia Research Institute
10:00 am – 10:30 am
Redox Regulation of the Epigenetic Landscape in Cancer: DNA methylation and Beyond
Rick Domann, Ph.D., The University of Iowa
10:30 am – 11:00 am
Break
11:00 am – 11:30 am
The Control of Histone Methylation and Gene Expression by Oxidative Stress, Hypoxia and Metals
Max Costa, Ph.D., NYU School of Medicine
11:30 am – 12:00 pm
Cardiovascular Risk Factors Impact the Endothelium via Epigenetic Regulation of the Redox State
Kaikobad Irani, MD, University of Pittsburgh
12:00 pm - 12:30 pm
SFRBM Member Meeting
12:30 pm – 2:30 pm
Lunch
Attendees on own or attend a professional development session
12:45 pm – 1:45 pm
PROFESSIONAL DEVELOPMENT SESSION I
How to Promote Academic-Biotechnology Interactions
Bruce Freeman, Ph.D., University of Pittsburgh
12:45 pm – 1:45 pm
PROFESSIONAL DEVELOPMENT SESSION II
How to Interview and be Interviewed Successfully
Victor Darley-Usmar, Ph.D., University of Alabama at Birmingham
2:30 pm – 4:30 pm
Oral presentations from submitted abstracts
(3 concurrent sessions)
4:30 pm – 6:30 pm
Formal Poster Presentations
6:30 pm – 8:00 pm
FRBM Editorial Board Reception
6:30 pm – 9:00 pm
Opening Doors Event
The Art of Leadership in Science
This year’s event will provide SFRBM members at all career levels an opportunity to review and discuss the general attributes of a good leader and how we can all effectively incorporate these skills into our daily lives in order to achieve our professional and personal goals. Scientific careers have become extremely specialized and greater emphasis is being placed on interdisciplinary research. Therefore the Opening Doors event will be highlighting the art of effectively leading groups of individuals.
Organized by Page Spiess, Ph.D., University of Vermont, Aimee Landar, Ph.D., University of Alabama at Birmingham, and the Women in Science Committee (WIS)
FRIDAY, NOVEMBER 18, 2011
SUNRISE FREE RADICAL SCHOOL
Back to the Basics
Chairs: Brian Day, Ph.D., National Jewish Medical & Research Center and Sruti Shiva, Ph.D., University of Pittsburgh
8:00 am – 8:30 am
Oxidative Models of Parkinson’s Disease
J. Timothy Greenamyre, MD, Ph.D., University of Pittsburgh
8:30 am – 9:00 am
Targeting Oxidative Stress in Neurodegenerative Diseases
Manisha Patel, Ph.D., University of Colorado
PLENARY SESSION
Oxidative Stress in Neurodegenerative Diseases
Chairs: Jianhua Zhang, Ph.D., University of Alabama at Birmingham and Anumantha Kanthasamy, Ph.D., Iowa State University
Oxidative stress plays a critical role in nervous system disease pathogenesis. Maintenance of balance between oxidants and anti-oxidants is critical for neuronal survival and glia function. Understanding how specific targets of oxidative stress play a role in neurological diseases are important for design of new therapeutic strategies.
9:30 am – 10:00 am
Oxidative Stress and Parkinson’s: Linking Alpha-Synuclein to Epigenetics
Julie Andersen, Ph.D., Buck Institute for Age Research
10:00 am – 10:30 am
Mitochondrial Abnormalities and Oxidative Stress in Alzheimer's Disease
Xiongwei Zhu, Ph.D., Case Western Reserve University
10:30 am – 11:00 am
Break
11:00 am – 11:30 am
Mitochondrial Dysfunction and Oxidative Stress in Astrocytes: A Role in Amyotrophic Lateral Sclerosis
Patricia Cassina, Ph.D., Universidad de la República, Uruguay
11:30 am – 12:00 pm
Nitrosative Signaling in Cell Death and Cell Survival
Ted Dawson, MD, Ph.D., Johns Hopkins University
12:00 pm – 12:30 pm
SFRBM DISCOVERY AWARD LECTURE
Biological Chemistry of Peroxynitrite: Relevance to Molecular Mechanisms of Disease and Therapeutics
Rafael Radi, MD, Ph.D., Universidad de la República, Uruguay
12:30 pm – 2:30 pm
Lunch
Attendees on own or attend a professional development session
12:45 pm – 1:45 pm
PROFESSIONAL DEVELOPMENT SESSION III
How to Write the Training Plan of a Fellowship Application
Paul Brookes, Ph.D., University of Rochester
12:45 pm – 1:45 pm
PROFESSIONAL DEVELOPMENT SESSION IV
How to Give an Effective Short Presentation
Aimee Landar, Ph.D., University of Alabama at Birmingham
2:30 pm – 4:30 pm
Oral presentations from submitted abstracts
(3 concurrent sessions)
4:30 pm – 6:30 pm
Formal Poster Presentations
SATURDAY, NOVEMBER 19, 2011
SUNRISE FREE RADICAL SCHOOL
Back to the Basics
Chairs: Brian Day, Ph.D., National Jewish Medical & Research Center and Sruti Shiva, Ph.D., University of Pittsburgh
8:00 am – 8:30 am
Metabolic Oxidative Stress and Cancer
Doug Spitz, Ph.D., The University of Iowa
8:30 am – 9:00 am
Mitochondrial Biogenesis and Redox Regulation
Claude Piantadosi, MD, Duke University
PLENARY SESSION
Mitochondria, Redox Metabolism and Cancer Biology
Chairs: Paul S. Brookes, Ph.D., University of Rochester and Sruti Shiva, Ph.D., University of Pittsburgh
Despite recent advances in mitochondrial research, there remain fundamental unanswered questions... Exactly what proteins do mitochondria contain? How does mitochondrial morphology relate to function? What regulates mitochondrial redox state? How do mitochondria contribute to cancer cell biology? These issues and more will be addressed.
9:30 am – 10:00 am
Genetic Insights into Warburg Effect Reveal
Tumor Promoting Function of UCP2
Keshav Singh, Ph.D., University of Alabama at Birmingham
10:00 am – 10:30 am
p53, Aerobic Metabolism and Cancer
Paul Hwang, MD, Ph.D., NHLBI - NIH
10:30 am – 11:00 am
Break
11:00 am – 11:30 am
Mitochondrial Morphology - Critical for Redox Signaling
Yisang Yoon, Ph.D., University of Rochester
11:30 am – 12:00 pm
SIRT6, A Master Regulator of Glucose Homeostasis and Cancer Metabolism
Raul Mostoslavsky, MD, Ph.D., Massachusetts General Hospital
12:00 pm – 12:30 pm
New Member Meeting
12:00 pm – 2:30 pm
Lunch (attendees on own)
2:30 pm – 4:30 pm
Oral presentations from submitted abstracts
(3 concurrent sessions)
4:30 pm – 6:30 pm
Formal Poster Presentations
7:30 pm – 9:30 pm
Closing/Awards Banquet
SUNDAY, NOVEMBER 20, 2011
PLENARY SESSION
Crosstalk Between NO and H2S Signaling
Chairs: Michael Graham Espey, Ph.D., NIH, and Bulent Mutus, Ph.D., University of Windsor, Canada
An emergent area of research involves hydrogen sulfide (H2S) as a companion gaseous mediator to nitric oxide (NO). Both are ubiquitous cellular signaling molecules with multiple physiological roles, including the regulation of blood pressure, inflammation and neuronal function. Chemically, NO and H2S interact directly yielding nitroxyl and other, as yet, uncharacterized products. H2S can react with NO-buffers such as nitrite or RSNOs to release NO. There are also growing lines of evidence that NO and H2S interact indirectly through their signaling pathways. The speakers in this plenary session are internationally renown experts who are actively engaged in research to investigate the crosstalk between H2S and NO-signaling.
9:00 am – 9:30 am
Chemical Interactions of Hydrogen Sulfide With Nitrogen Oxides
S. Bruce King, Ph.D., Wake Forest University
9:30 am – 10:00 am
H2S Regulation of NO Bioavailability: Mechanisms and Cytoprotective Effects
Chris Kevil, Ph.D., LSU Health Sciences Center
10:00 am – 10:30 am
Break
10:30 am – 11:00 am
The Search for an Endothelium-Derived Hyperpolarizing Factor - from NO to H2S
Rui Wang, MD, Ph.D., FAHA, Lakehead University, Canada
11:00 am – 11:30 am
Hydrogen Sulfide and Nitric Oxide Interactions in Inflammation
Matt Whiteman, Ph.D., University of Exeter, UK
11:30 am
Adjourn
