PLENARY SESSION
Nitric Oxide and Oxygen: Co-Conspirators for Life
Chairs: Sruti Shiva, Ph.D., University of Pittsburgh and Douglas Thomas, Ph.D., University of Illinois at Chicago
Since its initial characterization as endothelial derived relaxing factor, nitric oxide (NO) has been tightly linked to oxygen (O2). The unique relationship between these two molecules is important for most physiological and pathological conditions, ranging from cellular bioenergetics to inflammation and adaptation to high altitude. This session will focus on the different mechanisms by which NO and O2 modulate the production and metabolism of one another as well as their interactions with specific protein targets.
9:00 am - 9:30 am
NO Interactions with Mitochondrial Cytochrome c and Cytochrome Oxidase
Chris Cooper, Ph.D., University of Essex, UK
9:30 am - 10:00 am
Oxygen-Dependent Regulation of NO Production
Cynthia Otto, Ph.D., University of Pennsylvania
10:00 am - 10:30 am
Break
10:30 am - 11:00 am
Nitrite: A Hypoxic NO Donor and Vasodilator
Mark Gladwin, MD, UPMC Montefiore
11:00 am - 11:30 am
Nitric Oxide Levels and Adaptation to High Altitude Hypoxia
Serpil Erzurum, MD, The Cleveland Clinic Foundation
11:30 am
Adjourn